abstract：:The aim of this study was to investigate the effect of betaine (BET) on alcoholic liver fibrosis in rats. Fibrosis was experimentally generated with ethanol plus carbon tetrachloride (ETH+CCl4) treatment. Rats were treated with ETH (5% v/v in drinking water) for 14 weeks. CCl4 was administered intraperitoneally (i.p.)...

journal_title：Environmental toxicology and pharmacology

authors： Bingül İ,Başaran-Küçükgergin C,Aydın AF,Çoban J,Doğan-Ekici I,Doğru-Abbasoğlu S,Uysal M

更新日期：2016-07-01 00:00:00

abstract：:Mitochondrial damage can trigger mitophagy and eventually suppress proliferation. However, the effect of mitophagy on proliferation remains unclear. In this study, HepG2 cells were used to assess mitophagy and proliferation arrest in response to As2O3 exposure. The stimulatory effect of As2O3 on mitophagy was investig...

journal_title：Environmental toxicology and pharmacology

authors： Niu Z,Zhang W,Gu X,Zhang X,Qi Y,Zhang Y

更新日期：2016-07-01 00:00:00

abstract：:This study aims to investigate potential toxic effects of chrysene (CHR) on mature scallop Chlamys farreri during the reproduction period, using indicators of antioxidant defences and oxidative stress. Scallops were exposed to 0.2, 0.8 and 3.2μg/L waterborne CHR for 21 days, at day 10 scallops were induced to spawn. A...

journal_title：Environmental toxicology and pharmacology

authors： Xiu M,Pan L,Jin Q

更新日期：2016-06-01 00:00:00

abstract：:This study was to investigate the combined toxicity of silica nanoparticles (SiNPs) and methylmercury (MeHg) on cardiovascular system in zebrafish (Danio rerio) embryos. Ultraviolet absorption analysis showed that the co-exposure system had high absorption and stability. The dosages used in this study were based on th...

journal_title：Environmental toxicology and pharmacology

authors： Duan J,Hu H,Li Q,Jiang L,Zou Y,Wang Y,Sun Z

更新日期：2016-06-01 00:00:00

abstract：:We previously observed that nonylphenol (NP) exposure during development resulted in increases in body weight and hyperadrenalism in adult male offspring. The mechanism of hyperadrenalism includes the primary activation of the adrenal gland and the conversion of inactive glucocorticoids to active glucocorticoids by 11...

journal_title：Environmental toxicology and pharmacology

authors： Chang LL,Wun WS,Wang PS

更新日期：2016-06-01 00:00:00

abstract：:Eriocaulon sieboldianum (Sieb. & Zucc. ex Steud.), a genus of Eriocaulon in the Eriocaulaceae family, is an edible and medicinal plant used in traditional Chinese medicine. It was processed into healthcare beverages for expelling wind-heat, protecting eyes, and reducing blood fat. Also, it has been used with other her...

journal_title：Environmental toxicology and pharmacology

authors： Fan Y,Lu H,An L,Wang C,Zhou Z,Feng F,Ma H,Xu Y,Zhao Q

更新日期：2016-04-01 00:00:00

abstract：:Deoxynivalenol (DON) has broad toxicity in animals and humans. In this study the impact of DON treatment on apoptotic pathways in PC12 cells was determined. The effects of DON were evaluated on (i) typical indicators of apoptosis, including cellular morphology, cell activity, lactate dehydrogenase (LDH) release, and a...

journal_title：Environmental toxicology and pharmacology

authors： Wang X,Xu W,Fan M,Meng T,Chen X,Jiang Y,Zhu D,Hu W,Gong J,Feng S,Wu J,Li Y

更新日期：2016-04-01 00:00:00

abstract：:Recent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil was orally administered to rats (30 mg/kg/day) during 15 days (Fipronil...

journal_title：Environmental toxicology and pharmacology

authors： Chaguri JL,Godinho AF,Horta DF,Gonçalves-Rizzi VH,Possomato-Vieira JS,Nascimento RA,Dias-Junior CA

更新日期：2016-03-01 00:00:00

abstract：:Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and w...

journal_title：Environmental toxicology and pharmacology

authors： Cao Z,Fu Y,Sun X,Zhang Q,Xu F,Li Y

更新日期：2016-03-01 00:00:00

abstract：:Endothelial nitric oxidase synthase (eNOS) uncoupling plays a causal role in endothelial dysfunction in atherosclerosis. Genistein consumption has been associated with the prevention of atherosclerosis. However, the effect of genistein on eNOS uncoupling has not been reported. A model of oxidized low-density lipoprote...

journal_title：Environmental toxicology and pharmacology

authors： Zhang HP,Zhao JH,Yu HX,Guo DX

更新日期：2016-03-01 00:00:00

abstract：:We investigated the effect of phytosterol (PS) in regard to liver damage induced by 4-nitrophenol (PNP). Twenty rats were randomly divided into four groups (Control, PS, PNP, and PNP+PS). The PS and PNP+PS groups were pretreated with PS for one week. The PNP and PNP+PS groups were injected subcutaneously with PNP for ...

journal_title：Environmental toxicology and pharmacology

authors： Chen J,Song M,Li Y,Zhang Y,Taya K,Li C

更新日期：2016-01-01 00:00:00

abstract：:Grape-seed proanthocyanidins (GSPs) have been shown to function as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. However, little is known about their anti-inflammatory properties and mechanisms of action. The specific focus being its effects on the MAP kinases and nuclear facto...

journal_title：Environmental toxicology and pharmacology

authors： Chu H,Tang Q,Huang H,Hao W,Wei X

更新日期：2016-01-01 00:00:00

abstract：:This study aimed to observe the therapeutic effects of magnesium lithospermate B on acute and chronic colitis induced by dextran sodiumsulfate (DSS) and the role of inflammasome complex (NOD-like receptor protein, NLRP; apoptosis-associated speck-like protein containing, ASC; caspase-1). Establishment of acute and chr...

journal_title：Environmental toxicology and pharmacology

authors： Jiang X,Zhong L,Sun D,Rong L

更新日期：2016-01-01 00:00:00

abstract：:Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...

journal_title：Environmental toxicology and pharmacology

authors： Stypuła-Trębas S,Minta M,Radko L,Żmudzki J

更新日期：2015-11-01 00:00:00

abstract：:Nano-size zinc oxide particles (ZnO NPs) are used in diverse industrial and commercial fields. However, the information from existing studies is not sufficient in evaluating the potential toxic effects of ZnO NPs. In this study, tilapia fish (Oreochromis niloticus) were exposed to different concentrations of small and...

journal_title：Environmental toxicology and pharmacology

authors： Kaya H,Aydın F,Gürkan M,Yılmaz S,Ates M,Demir V,Arslan Z

更新日期：2015-11-01 00:00:00

abstract：:Mining activities including mineral excavation and ore transportation produce and release large amounts of pollutants to the surrounding environment, raising concerns regarding the effects of environmental exposure to pollutants on human health. The concentration of elements in hair can be used as a biomarker of expos...

journal_title：Environmental toxicology and pharmacology

authors： Pan Y,Li H

更新日期：2015-11-01 00:00:00

abstract：:In utero exposure of neonates to pesticide residues could be damaging to the reproductive tract. Hence, the present study assessed the circulating concentrations of pesticide residues in buffalo and their neonatal calves as well as in the reproductive tract tissue samples of same calves. Also, histopathological altera...

journal_title：Environmental toxicology and pharmacology

authors： Kaur K,Ghuman SS,Singh O,Bedi JS,Gill JP

更新日期：2015-11-01 00:00:00

abstract：:Combretastatin A-4 exhibits efficient anti-cancer potential in human tumors, including multidrug-resistant tumors. We evaluated the mutagenic, apoptotic and immunomodulatory potential of two diaryl sulfide analogs of combretastatin A-4, 1,2,3-trimethoxy-5-([4-methoxy-3-nitrophenyl]thio)benzene (analog 1) and 1,2,3-tri...

journal_title：Environmental toxicology and pharmacology

authors： Carvalho PC,Santos EA,Schneider BU,Matuo R,Pesarini JR,Cunha-Laura AL,Monreal AC,Lima DP,Antoniolli AC,Oliveira RJ

更新日期：2015-11-01 00:00:00

abstract：:CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing...

journal_title：Environmental toxicology and pharmacology

authors： Wang T,Zhang X,Tian D,Gao Y,Lin Z,Liu Y,Kong L

更新日期：2015-11-01 00:00:00

abstract：:Electrocardiogram and arterial pressure measurements were studied under acute exposures to WIFI (2.45GHz) during one hour in adult male rabbits. Antennas of WIFI were placed at 25cm at the right side near the heart. Acute exposure of rabbits to WIFI increased heart frequency (+22%) and arterial blood pressure (+14%). ...

journal_title：Environmental toxicology and pharmacology

authors： Saili L,Hanini A,Smirani C,Azzouz I,Azzouz A,Sakly M,Abdelmelek H,Bouslama Z

更新日期：2015-09-01 00:00:00

abstract：:The use of solid fuels for cooking and heating is likely to be the largest source of indoor air pollution on a global scale; these fuels emit substantial amounts of toxic pollutants such as polycyclic aromatic hydrocarbons (PAHs) when used in simple cooking stoves (such as open "three-stone" fires). Moreover, indoor a...

journal_title：Environmental toxicology and pharmacology

authors： Ruiz-Vera T,Pruneda-Álvarez LG,Ochoa-Martínez ÁC,Ramírez-GarcíaLuna JL,Pierdant-Pérez M,Gordillo-Moscoso AA,Pérez-Vázquez FJ,Pérez-Maldonado IN

更新日期：2015-09-01 00:00:00

abstract：:To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. T...

journal_title：Environmental toxicology and pharmacology

authors： Takuma M,Ushijima K,Kumazaki M,Ando H,Fujimura A

更新日期：2015-09-01 00:00:00

abstract：:Sodium fluoride (NaF), used as pesticides and for industrial purposes are deposited in the water bodies and therefore affects its biota. Zebrafish exposed to NaF in laboratory condition showed hyperactivity and frequent surfacing activity, somersaulting and vertical swimming pattern as compared to the control group. R...

journal_title：Environmental toxicology and pharmacology

authors： Mukhopadhyay D,Priya P,Chattopadhyay A

更新日期：2015-09-01 00:00:00

abstract：:To explore the effects of microcystin-LR (MC-LR), a hepatotoxin, on the incidence of liver lipid metabolism abnormality, and the potential molecular mechanisms of action, healthy male Balb/c mice were intraperitoneally injected with MC-LR at doses of 0, 5, 10, and 20 μg/kg/d for 14 days. Hepatic histopathology and ser...

journal_title：Environmental toxicology and pharmacology

authors： Qin W,Zhang X,Yang L,Xu L,Zhang Z,Wu J,Wang Y

更新日期：2015-07-01 00:00:00

abstract：:There are significant challenges in assessing the toxicity of nanoparticles in the environment in which effective methods for detection are crucial. An inexpensive method that uses superhydrophobic well with an evaporating droplet followed by a simple squeeze flow is described here and found to provide practical high ...

journal_title：Environmental toxicology and pharmacology

authors： Cheong BH,Muradoglu M,Liew OW,Ng TW

更新日期：2015-07-01 00:00:00

abstract：:The relationship between fluorosis and the lifestyle of adult residents of areas in which fluorosis is endemic was evaluated. A cross-sectional and case-control analysis was performed to study 289 villagers living in fluorosis endemic areas who drank the local water. Subjects were divided into skeletal fluorosis and n...

journal_title：Environmental toxicology and pharmacology

authors： Liu G,Ye Q,Chen W,Zhao Z,Li L,Lin P

更新日期：2015-07-01 00:00:00

abstract：:We previously reported that Astragalus polysaccharide (APS) extracted from Chinese medicine Astragalus membranaceus (Fisch.) Bge, attenuates hypertrophy of neonatal rat ventricular myocytes (NRVMs) induced by isoproterenol (Iso). The present study was designed to investigate the effects and the possible mechanism of A...

journal_title：Environmental toxicology and pharmacology

authors： Luan A,Tang F,Yang Y,Lu M,Wang H,Zhang Y

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:This study aimed at evaluation of selected spirometric parameters in persons occupationally exposed to lead without evident health problems. The studies were conducted on 69 men occupationally exposed to lead. Occupational exposure to lead was characterized by estimation of blood lead concentration (Pb-B) an...

journal_title：Environmental toxicology and pharmacology

authors： Jurdziak M,Gać P,Martynowicz H,Poręba R

更新日期：2015-05-01 00:00:00

abstract：:Emamectin benzoate (EB) is an avermectin insecticide used extensively in pest control on vegetable and field crops. Few studies have been done for evaluating adverse effects of EB. In the current study, we evaluated the toxic effects of EB on male rats and the possible ameliorative role of fennel essential oil (FEO). ...

journal_title：Environmental toxicology and pharmacology

authors： El-Sheikh el-SA,Galal AA

更新日期：2015-05-01 00:00:00

abstract：:Cadmium (Cd) and lead (Pb) show adverse effects on hemoglobin. But most studies are focussed on one single agent. In this study, we observed the main and interactive effects of Cd and Pb on the hemoglobin level in a Chinese population. A total of 308 persons (202 women and 106 men), living in controlled and polluted a...

journal_title：Environmental toxicology and pharmacology

authors： Chen X,Zhou H,Li X,Wang Z,Zhu G,Jin T

更新日期：2015-03-01 00:00:00

abstract：:In this study we analyzed and characterized 29 psychoactive remedies, illicit drugs and their metabolites in single stages of wastewater treatment plants in the capital city of Slovakia. Psychoactive compounds were present within all stages, and tramadol was detected at a very high concentration (706 ng/L). Significan...

journal_title：Environmental toxicology and pharmacology

authors： Mackuľak T,Mosný M,Škubák J,Grabic R,Birošová L

更新日期：2015-03-01 00:00:00

abstract：:The use of surfactants in the development of a suitable formulation for insecticides should improve the solubility behavior, the permeability and the efficiency against pests meanwhile decrease the toxic risks of insecticides on human health. Cytotoxicity of insecticides including abamectin, chlorfluazuron, hexaflumur...

journal_title：Environmental toxicology and pharmacology

authors： Li D,Wu X,Yu X,Huang Q,Tao L

更新日期：2015-03-01 00:00:00

abstract：:Deferasirox (commercially formulated as Exjade(®)) is one of the effective iron chelators used in treatment of iron overload diseases. In this study the effect of this substance for chromosome aberration, sister chromatid exchange and mitotic index was studied by in vitro (by using human peripheral lymphocytes) and in...

journal_title：Environmental toxicology and pharmacology

authors： Arslan M,Ila HB

更新日期：2015-03-01 00:00:00

abstract：:Carbon monoxide (CO) intoxication is one of the most common types of poisoning worldwide, and may result in neuropathologic sequelae, yet its pathogenesis is not clear and there is no optimal management strategy for patients with CO poisoning. In this study, the rat model of CO poisoning was established in a hyperbari...

journal_title：Environmental toxicology and pharmacology

authors： Li Q,Cheng Y,Bi MJ,Kang H,Qu Y,Lin H,Guo Y,Zou Y

更新日期：2015-03-01 00:00:00

abstract：:The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soy...

journal_title：Environmental toxicology and pharmacology

authors： Kostogrys RB,Franczyk-Żarów M,Maślak E,Topolska K

更新日期：2015-03-01 00:00:00

abstract：:The present study evaluated the mutagenic and recombinogenic effects of two commonly used anesthetic agents, ketamine and rocuronium bromide, in medicine using the wing somatic mutation and recombination test (SMART) in Drosophila. The standard (ST) cross and the high-bioactivation (HB) cross with high sensitivity to ...

journal_title：Environmental toxicology and pharmacology

authors： Koksal PM,Gürbüzel M

更新日期：2015-03-01 00:00:00

abstract：:Association of arsenic exposure with smoking, alcohol, and caffeine consumption was investigated. Data from National Health and Nutrition Examination Survey for the years 2005-2010 were used for this investigation. Urinary levels of total arsenic (UAS) and dimethylarsonic acid (UDMA) were evaluated for children aged 6...

journal_title：Environmental toxicology and pharmacology

authors： Jain RB

更新日期：2015-03-01 00:00:00

abstract：:The existing hazard of joint mycotoxin exposure of animals/humans and the significance of masked mycotoxins in foods or feeds and their respective contributions to the development of some food born mycotoxicoses is briefly reviewed. The importance of joint mycotoxin interaction in the complex etiology of some foodborn...

journal_title：Environmental toxicology and pharmacology

authors： Stoev SD

更新日期：2015-03-01 00:00:00

abstract：:Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxida...

journal_title：Environmental toxicology and pharmacology

authors： Jung HY,Seo DW,Hong CO,Kim JY,Yang SY,Lee KW

更新日期：2015-01-01 00:00:00

abstract：:We recently reported that acrylamide, a known rodent and probable human carcinogen, does not increase the risk of azoxymethane (AOM)-induced rat colon precancerous lesions when administered through the diet. Here, we present toxicological data from non-AOM-injected rats. Briefly, male F344 rats were randomized into fo...

journal_title：Environmental toxicology and pharmacology

authors： Raju J,Roberts J,Taylor M,Patry D,Chomyshyn E,Caldwell D,Cooke G,Mehta R

更新日期：2015-01-01 00:00:00